LOUISVILLE, Ky. (AP) -- Reserve guard Brandon Jenkins scored a career-high 14 points and backup forward Otis George had 13 points and 10 rebounds to lead Louisville to a 92-41 win over East Carolina on Wednesday night.
Taquan Dean scored 13 and Juan Palacios had 12 points and 10 rebounds for the No. 14 Cardinals (15-3, 4-1 Conference USA), who dominated from the start, propelled by sharp 3-point shooting and suffocating full-court pressure.
Moussa Badiane had 16 points and 16 rebounds for the sloppy Pirates (5-12, 0-5), who committed 24 turnovers and shot 26 percent (15-of-58) in losing for the 10th time in 11 games.
Coming off a 69-66 victory at then-No. 18 Cincinnati last Saturday, the Cardinals led 52-15 at halftime and were never challenged in the second half, allowing coach Rick Pitino to get plenty of minutes for his bench players.
Leading scorer Francisco Garcia scored only nine points in 22 minutes.
Since a 60-58 loss to Kentucky on Dec. 18, Louisville has won seven home games by an average of 34 points.
The Cardinals jumped to a 14-3 lead by sinking shots from the outside and avoiding Badiane, the league's second-leading shot blocker. Louisville started 5-for-15 from the floor, but three of the baskets were 3-pointers.
The 6-foot-10 Badiane scored three of the Pirates' first four baskets and his layup with 11:27 left in the half cut Louisville's lead to 18-9.
Larry O'Bannon then sparked a 10-0 Louisville spurt with a 3-pointer from the corner near the 11-minute mark.
The Cardinals came in averaging 9.6 3-pointers per game, fifth in the nation, and had nine by halftime - half of their 18 first-half field goals.
The flustered Pirates averaged 17 turnovers in their first four league games, but had 15 at the break on Wednesday.
Despite the comfortable edge, Pitino remained feisty. When Ellis Myles picked up a foul with 16:43 left in the game, Pitino slammed a tin of mints onto the scorers' table, spraying some on the floor.
The Cardinals missed 11 of their first 12 shots after halftime, but the Pirates never mounted a charge.